Journal article
The prognostic value of TP53 mutations in oesophageal adenocarcinoma: A systematic review and meta-analysis
OM Fisher, SJ Lord, D Falkenback, NJ Clemons, GD Eslick, RV Lord
Gut | Published : 2017
Abstract
Objective To clarify the prognostic role of tumour protein 53 (TP53) mutations in patients with oesophageal adenocarcinoma (OAC) as there is a need for biomarkers that assist in guiding management for patients with OAC. Design A systematic review was conducted using MEDLINE, Embase, PubMed and Current Contents Connect to identify studies published between January 1990 and February 2015 of oesophageal cancer populations (with OAC diagnoses >50% of cases) that measured tumoural TP53 status and reported hazard ratios (HR), or adequate data for estimation of HR for survival for TP53-defined subgroups. Risk of bias for HR estimates was assessed using prespecified criteria for the appraisal of rel..
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Awarded by Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Funding Acknowledgements
This work was supported by the Progression of Barrett's Esophagus Network (PROBE-Net, Chief Investigator David C. Whiteman) and by the Australian National Health and Medical Research Council (NHMRC 1040947), Cancer Council New South Wales (SRP 08-04 and RG 13-03) and St Vincent's Clinic Foundation, Sydney.